Publications

  • Blomqvist, K.E., Yang, Y., Huang, H., Karbstein, K. (in revision) Unstructured Domains in Assembly Factors Promote the Hierarchy of Ribosome Maturation via their Structural Plasticity. BioRxiv https://doi.org/10.1101/2023.11.23.568400
  • Blomqvist, K.E., Huang, H. & Karbstein, K. (submitted) A disease associated mutant reveals how Ltv1 orchestrates RP assembly and rRNA folding of the small ribosomal subunit head. PLoS Genet.2023 Nov;19(11):e1010862.

  • Parker, M.P. & Karbstein, K. (2023) Quality control ensures the fidelity of ribosome assembly and human health. J Cell Biol. 222(4):e202209115

  • Yang, Y-M., Jung, Y., Abegg, D., Adebekian, A., Carroll, K.S. & Karbstein, K. (2023) Chaperone-directed ribosome repair after oxidative stress. Molecular Cell 83(9):1527-1537 [Preview by Spiri&Brar (2023) Mol Cell 83(9):1374-1376]

  • Parker, M.P., Getzler, A. & Karbstein, K. (in revision) The kinase Rio1 and a ribosome collision-dependent decay pathway survey the integrity of 18S rRNA cleavage. BioRxiv https://doi.org/10.1101/2022.07.29.501969 

  • Liu, X., Huang, H. & Karbstein, K. (submitted) The DEAD-box ATPase Has1 regulates a conformational rearrangement in early 40S assembly intermediates that prevents platform misassembly. BioRxiv https://doi.org/10.1101/2021.09.06.459192

  • Karbstein, K. (2022) The cost of ribosome heterogeneity. Molecular Cell 82(12):2179-2184.

  • Yang, Y-M. & Karbstein, K. (2022) The chaperone Tsr2 regulates Rps26 release and reincorporation from mature ribosomes to enable a reversible, ribosome-mediated response to stress.   Science Advances 8(8):eable4386.
  • Huang, H., Parker, M.D. & Karbstein, K. (2022) The rRNA modifying enzyme Tsr3 coordinates the activity of the Rio1 and Rio2 kinases during 40S ribosome assembly. RNA doi: 10.1261/rna.078994.121

  • Karbstein, K. (2022) Attacking a DEAD Problem: The Role of DEAD-box ATPases in Ribosome Assembly and beyond. Methods in Enzymology

  • Liu, X., Huang, H. & Karbstein, K. (2022) Using DMS-MaPseq to Uncover the Roles of DEAD-box Proteins in Ribosome Assembly. Methods 204: 249-257.

  • Huang, H. & Karbstein, K. (2021) Assembly factors chaperone rRNA folding by isolating helical junctions that are prone to misfolding. Proceedings of the National Academy of Sciences 118(25):e2101164118.

  • Rai, J.*, Parker, M.P.*, Huang, H., Choy, S. Ghalei, H., Johnson, M.C., Karbstein, K. & Stroupe, M.E. (2021) An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7. RNA 27(2): 221-233.
  • Huang, H., Ghalei, H & Karbstein, K. (2020) Quality control during head assembly ensures scanning competence J Cell Biol. 219(11):e202004161.